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Biomimetic Models Of Disease

The development of safe and effective medical devices relies on accurate testing platforms which are used for their evaluation prior to human use. Current models of disease such as valvular heart disease, congenital disease, and heart failure cannot mimic disease with high fidelity, and their ability to predict the efficacy of medical treatments is limited.

 

In my work, I develop soft robotic tools that can be implanted to recreate the biomechanics and hemodynamics of cardiovascular disease in a highly tunable and customizable way. I developed soft robotic cardiac and aortic sleeves that can mimic the anatomy and function of a patient’s heart and aortic valve in both physiology and disease. In animal models, these sleeves can recapitulate human disease with high-fidelity. These models can be used for device development and personalized interventional planning.

L. Rosalia*, S. Wang*, C. Ozturk, W. Huang, J. Bonnemain, R. Beatty, G.P. Duffy, C.T. Nguyen, E.T. Roche, “Soft robotic platform for controlled, progressive and reversible aortic constriction in a small animal model”. In revision (2023).

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M.A. Horvath, D. Van Story, L. Rosalia, B. Starr, M. Jiang, D. Annese, B. Piekarski, C. Ozturk, S. Agudelo, K. Brassaw, M. Valenza, E. Herdes, A. Powell, P. del Nido, E.T. Roche, “Recapitulation of single ventricle hemodynamics and associated interplay with breathing mechanics using clinically validated multimodal simulators”. In revision (2023). Link

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L. Rosalia, C. Ozturk, D. Goswami, J. Bonnemain, S. Wang, B. Bonner, J. Weaver, Rishi Puri, Samir Kapadia, C.T. Nguyen, E.T. Roche, “Soft robotic patient-specific hydrodynamic model of aortic stenosis and ventricular remodeling”, Sci. Robot., 8 (75), 2023.  Link

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L. Rosalia*, C. Ozturk*, J. Coll-Font, Y. Fan, Y. Nagata, M. Singh, D. Goswami, A. Mauskapf, S.A. Chen, R.A. Eder, J. Kim, S. Yurista, B.P. Bonner, A.N. Foster, R.A. Levine, E.R. Edelman, M. Panagia, J. Guerrero, E.T. Roche, C.T. Nguyen, “A soft robotic sleeve mimicking the haemodynamics and biomechanics of left ventricular pressure overload and aortic stenosis”, Nat. Biomed. Eng, 6 (1134–1147), 2022.  Link. Featured on the issue cover

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M. Horvath*, L. Hu*, T. Mueller, J. Hochstein, L. Rosalia, K.A. Hibbert, C.C. Hardin, E.T. Roche, “An organosynthetic soft robotic respiratory simulator”, APL Bioengineering, 4 (026108),2020. Link

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Related Coverage: Phys.org, Drug target review.

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